منابع مشابه
Compete Globally, Bud Locally
How cells generate a single axis of polarity for mating, division, and movement is unknown. In this issue, Howell et al. (2009) use a synthetic biology approach to demonstrate that rapid competition for a soluble signaling component (Bem1) is essential to ensure a unique axis of polarity in budding yeast.
متن کاملThink globally, act locally
In a large cyber-physical system, even if individual system elements interact with one another only locally, effects of local decisions quickly spread across the system and combine to yield global consequences. In order to reason about such a system without impractical amounts of communication and computation, we must summarize the system’s global state, and base individual decisions at least p...
متن کاملThink globally, breathe locally.
polysaccharide pneumococcal vaccine adults in more developed countries: the state of the evidence. Lancet Infect Dis 2003;3:71–8. 8 Alfageme I, Vazquez R, Reyes N, et al. Clinical efficacy of anti-pneumococcal vaccination in patients with COPD. Thorax 2006;61:189–95. 9 Lexau CA, Lynfield R, Danila R, et al. Changing epidemiology of invasive pneumococcal disease among older adults in the era of ...
متن کاملPause locally, splice globally.
Most eukaryotic protein-coding transcripts contain introns, which vary in number and position along the transcript body. Intron removal through pre-mRNA splicing is tightly linked to transcription by RNA polymerase II as it translocates along each gene. Here, we review recent evidence that transcription and splicing are functionally coupled. We focus on how RNA polymerase II elongation rates im...
متن کاملThink globally, act locally
This issue of Asia Pacific Allergy (Asia Pac Allergy) will be released at the beginning of its third year of circulation. Asia Pac Allergy is just two years old yet very active and on the way to developing into a leading publication in allergic disease research. We thank all the authors and readers for their efforts and contributions. Our current issue features two valuable reviews on the topic...
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ژورنال
عنوان ژورنال: Cell
سال: 2009
ISSN: 0092-8674
DOI: 10.1016/j.cell.2009.10.028